The HMN24 Core Range, RISE, FLOW, and PRE-SLEEP, is designed in alignment with the body’s circadian biology, supporting metabolic function, cognitive performance, emotional regulation, and restorative sleep across the 24-hour cycle.
Rather than overriding physiology with stimulation or sedation, the formulations reinforce the endogenous neurochemical rhythms that naturally govern human performance (.
This system is grounded in three scientific pillars:
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1. Pharmacokinetics
Ingredients are selected based on:
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Bioavailability
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Absorption kinetics
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Neurochemical transport pathways
This ensures each compound reaches peak efficacy at the biologically appropriate time, for example, dopaminergic ignition in the morning, sustained acetylcholine signalling during deep work, and GABAergic calming and cortisol modulation before sleep (.
2. Arousal State Modulation
The HMN24 system supports healthy transitions across the daily arousal spectrum, influencing:
| Neurochemical | Function |
|---|---|
| Dopamine | Motivation, drive, cognitive effort |
| Acetylcholine | Learning efficiency, memory, mental switching |
| Cortisol | Circadian alertness curve regulation |
| GABA | Neural calming and emotional regulation |
| Endocannabinoid signalling | Parasympathetic recovery and sleep readiness |
Rather than pushing the body into highs or lows, HMN24 guides the rhythm.
3. Sleep-Wake Neurobiology
Every HMN24 formulation reinforces:
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Circadian phase stability
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REM/NREM sleep quality
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Glymphatic system overnight neural clearing
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Autonomic nervous system (ANS) recalibration
Sleep is treated not as the end of the day, but the foundation of tomorrow’s performance (.
Phase 1: Morning Activation
RISE
With first morning light, melanopsin-containing retinal cells signal the suprachiasmatic nucleus (SCN), triggering the cortisol awakening response and dopamine activation, preparing the brain for alertness and cognitive engagement (.
RISE amplifies this natural biological signal, rather than replacing it with stimulants.
Key Functional Mechanisms
| Ingredient | Mechanism | Outcome |
|---|---|---|
| Creatine Monohydrate (2.2g) | Restores neuronal ATP after overnight depletion | Enhances cognitive readiness and mental clarity |
| Citicoline (CDP-Choline, 250mg) | Increases acetylcholine synthesis | Improves working memory, learning speed, and task switching |
| ALCAR (500mg) | Enhances CNS mitochondrial energy metabolism | Supports metabolic ignition and sustained morning cognition |
| Natural Caffeine + L-Theanine | Balanced dopaminergic activation without sympathetic spike | Alertness without jitter, anxiety, or crash |
Light Sensitivity & Circadian Entrainment Enhancement
| Ingredient | Mechanism | Circadian Effect |
|---|---|---|
| Pyridoxal-5-Phosphate (B6 as P5P) | Co-factor for dopamine, serotonin & GABA synthesis | Enhances dopamine-driven alertness and reduces cognitive lag upon waking ( |
| Methylcobalamin (B12) | Supports optic nerve signal transmission & melatonin-daytime light rhythm | Strengthens retinal light signal → SCN entrainment, improving circadian alignment ( |
| B-Vitamin Complex (with P5P + Methylcobalamin) | Coordinates neurotransmitter and methylation pathways | Improves “light responsiveness” and stabilises daytime cognitive tone ( |
These nutrients increase the brain’s sensitivity to daylight, enabling a stronger shift into wakefulness, improved morning motivation, and a more stable circadian day/night boundary.
Outcome of RISE Phase
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Faster cognitive wakefulness
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Increased morning drive and clarity
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Reduced reliance on stimulants
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Stronger circadian entrainment for the rest of the day
Phase 2 : Cognitive Performance
FLOW
During peak work periods, sustained performance requires dopaminergic resilience, acetylcholine efficiency, and stress-tolerant focus (.
FLOW is formulated to support deep work without overstimulation:
| Ingredient | Mechanism | Outcome |
|---|---|---|
| N-Acetyl-L-Tyrosine | Dopamine precursor under cognitive demand | Maintains motivation, reduces fatigue-induced procrastination ( |
| Rhodiola Rosea (400mg) | Regulates sympathetic arousal and fatigue perception | Supports performance under psychological pressure ( |
| Lion’s Mane (NGF-supportive extract) | Promotes synaptic plasticity | Improves learning, adaptability, and long-term memory formation |
| Citicoline + Electrolytes | Sustain acetylcholine + neural hydration | Supports consistent cognitive throughput and screen endurance ( |
Outcome of FLOW Phase
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Sustained focus and cognitive endurance
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Improved stress tolerance and emotional steadiness
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Reduced mental fatigue and procrastination
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Ability to maintain deep work without overstimulation
Phase 3: Evening Transition
PRE-SLEEP
As daylight fades, the body transitions toward parasympathetic dominance and melatonin-governed sleep initiation. Cognitive slowing and stress down-regulation are critical (.
PRE-SLEEP supports this shift:
| Ingredient | Mechanism | Outcome |
|---|---|---|
| Phosphatidylserine (400mg) | Reduces HPA-axis hyperarousal | Eases mental "overdrive," improving sleep initiation |
| KSM-66 Ashwagandha (400mg) | Modulates cortisol + supports GABA activity | Promotes calm and emotional decompression |
| Magnesium Glycinate (200mg) | Neuromuscular and CNS relaxation | Improves sleep depth and continuity |
| Levagen+ (PEA) + L-Theanine | Endocannabinoid + alpha-wave relaxation | Supports transition from active cognition → restful sleep |
Outcome of PRE-SLEEP Phase
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Faster transition from wakefulness into sleep
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Reduced cognitive load and nighttime rumination
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Deeper REM and NREM sleep architecture
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Enhanced overnight recovery and improved next-day performance
Performance That Works With Biology
The HMN24 Core Range:
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Enhances cognitive performance without overstimulation
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Reduces reliance on caffeine and sleep aids
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Strengthens emotional and physiological resilience
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Improves sleep quality and next-day capacity
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Supports sustainable performance, not fragile performance
This is biologically intelligent performance, grounded in circadian science, neurochemistry, and pharmacokinetics rather than trends or stimulant dependency.
References
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Santhi, N. et al. (2016). Sex differences in the circadian regulation of sleep and waking cognition in humans. Proceedings of the National Academy of Sciences, 113(19), E2730–E2739. https://doi.org/10.1073/pnas.1521637113
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Law, R., & Clow, A. (2020). Stress, the cortisol awakening response, and cognitive function. International Review of Neurobiology, 150, 187–217. https://doi.org/10.1016/bs.irn.2020.01.001
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Krishnan, H., & Lyons, L. (2015). Synchrony and desynchrony in circadian clocks: impacts on learning and memory. Learning & Memory, 22(9), 426–437. https://doi.org/10.1101/lm.038877.115
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Fernandez, R. et al. (2003). Circadian modulation of long-term sensitization in Aplysia. Proceedings of the National Academy of Sciences, 100(24), 14415–14420. https://doi.org/10.1073/pnas.2336172100
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