One of the most important combinations of ingredients in RISE is the combination of Caffeine and Theanine.
Caffeine and theanine are compounds found in tea but have very different effects on our brains. Caffeine is a well-known stimulant that increases alertness and reduces fatigue, while theanine is an amino acid that promotes relaxation without sedation.
When combined, these two compounds can have a synergistic effect, enhancing cognitive performance and improving mood whilst regulating the sympathetic response we get from caffeine alone.
Caffeine: The Stimulant
- Mechanism of Action: Caffeine works by blocking adenosine receptors in the brain. Adenosine is a neurotransmitter that promotes relaxation and sleepiness. By blocking these receptors, caffeine reduces the feeling of tiredness and increases alertness (Smith, 2002) .
- Benefits: Increased energy, enhanced focus, improved reaction times, and elevated mood.
- Drawbacks: Can cause jitteriness, anxiety, increased heart rate, and potential for a "crash" when its effects wear off.
Theanine: The Calmer
- Mechanism of Action: Theanine promotes the production of calming neurotransmitters like GABA, dopamine, and serotonin. It also modulates alpha brain waves, associated with a relaxed yet alert mental state (Kimura et al., 2007)—one of the reasons you will also find it in HMN24 Pre-Sleep.
- Benefits: Reduces stress and anxiety, promotes relaxation without drowsiness, and can improve sleep quality (Lyon et al., 2011).
- Drawbacks: Theanine doesn’t have strong stimulant or sedative effects on its own, so its impact might be subtle.
Combining Caffeine and Theanine
- Balanced Effects: The combination of caffeine and theanine provides the stimulating benefits of caffeine without the jitteriness or anxiety that can sometimes accompany caffeine consumption. Theanine helps smooth out the stimulant effects, leading to calm alertness and the regulated nervous system stimulation we all desire (Haskell et al., 2008).
- Cognitive Enhancement: Studies have shown that the combination can improve cognitive performance more effectively than either compound alone. This includes better attention, memory, and learning capabilities (Owen et al., 2008).
- Mood Improvement: Theanine’s calming effects can counteract caffeine’s potential anxiety-inducing effects, leading to a more stable and improved mood (Rogers & Smith, 2011).
Scientific Evidence
Numerous studies have investigated the effects of combining caffeine and theanine:
Improved Attention and Accuracy: Research has shown that the combination can significantly enhance attention and accuracy in tasks requiring fast information processing (Einöther & Giesbrecht, 2013).
Enhanced Alertness and Relaxation: Participants report feeling more alert yet relaxed when taking both compounds together (Giesbrecht et al., 2010).
Reduced Jitteriness: Theanine's calming effects help mitigate the jitteriness often associated with caffeine, making it easier to focus without the distraction of feeling overly stimulated (Foxe et al., 2012).
Practical Applications
Dosage: Ratios used in studies vary but the 2:1 ratio of theanine to caffeine, such as 250mg of theanine and 125 mg of caffeine that you find in HMN24 RISE is the ratio with the most robust evidence.
Summary
Combining caffeine with theanine leverages the stimulating properties of caffeine and the calming effects of theanine to enhance cognitive performance, improve mood, and reduce the adverse side effects of caffeine.
This synergy creates the balanced state of increased alertness and relaxation, mental clarity, and focus we strive for when using RISE. It also helps us regulate and manage our all-important nervous system activity far more than with caffeine alone.
References:
Smith, A. (2002). Effects of caffeine on human behaviour. Food and Chemical Toxicology, 40(9), 1243-1255.
Einöther, S. J. L., & Giesbrecht, T. (2013). Caffeine as an attention enhancer: reviewing existing assumptions. Psychopharmacology, 225(2), 251-274.
Kimura, K., Ozeki, M., Juneja, L. R., & Ohira, H. (2007). L-Theanine reduces psychological and physiological stress responses. Biological Psychology, 74(1), 39-45.
Lyon, M. R., Kapoor, M. P., & Juneja, L. R. (2011). The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomised, double-blind, placebo-controlled clinical trial. Alternative Medicine Review, 16(4), 348-354.
Owen, G. N., Parnell, H., De Bruin, E. A., & Rycroft, J. A. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutritional Neuroscience, 11(4), 193-198.
Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., & Scholey, A. B. (2008). The effects of L-theanine, caffeine and their combination on cognition and mood. Biological Psychology, 77(2), 113-122.
Giesbrecht, T., Rycroft, J. A., Rowson, M. J., & De Bruin, E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional Neuroscience, 13(6), 283-290.
Einöther, S. J. L., & Martens, V. E. G. (2013). Acute effects of tea consumption on attention and mood. American Journal of Clinical Nutrition, 98(6), 1700S-1708S.
Einöther, S. J. L., & Giesbrecht, T. (2013). Caffeine as an attention enhancer: reviewing existing assumptions. Psychopharmacology, 225(2), 251-274.
Foxe, J. J., Morie, K. P., Laud, P. J., Rowson, M. J., De Bruin, E. A., & Kelly, S. P. (2012). Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task. Neuropharmacology, 62(7), 2320-2327.
Rogers, P. J., & Smith, J. E. (2011). Positive mood and cognitive performance: the synergistic effect of L-theanine and caffeine. Psychopharmacology, 217(2), 221-229.
Owen, G. N., Parnell, H., De Bruin, E. A., & Rycroft, J. A. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutritional Neuroscience, 11(4), 193-198.
Blog posts
The First 7 Minutes After Waking: Why They Matter More Than You Think
Modern neuroscience confirms what ancient traditions have practised for millennia: the first few minutes after you wake up are biologically powerful.
Your brain doesn’t flick on like a light switch. It transitions, slowly and delicately, through a cascade of brainwave states:
Delta → Theta → Alpha → Beta
These transitions reflect the shift from deep sleep (delta), through drowsiness and subconscious processing (theta), into relaxed awareness (alpha), and eventually into full alertness (beta).
Gamma, the fastest and most subtle of the brainwave frequencies, is typically associated with heightened cognitive processing, insight, and peak states of consciousness. While not dominant in the first few minutes of waking, gamma activity can emerge later in the morning, or more rapidly in trained meditators, when the brain begins to integrate thought, emotion, and sensory input into a coherent experience.
This means that during the first 5 to 10 minutes of wakefulness, you’re not fully asleep, but you’re not fully awake either. You’re in a unique, mouldable neurobiological state that scientists call a neuroplastic window, where your brain is most open to new programming.
This is your most influential moment of the day.
What’s Happening in Your Brain
During this waking transition:
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The Default Mode Network (DMN), the brain’s internal narrator, begins to light up. It controls self-talk, emotional tone, and how we perceive ourselves and the world (Smallwood et al., 2021; Edlow et al., 2024).
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The Reticular Activating System (RAS) switches on. It decides what’s important by scanning your environment through the lens of your current emotional state (Negelspach et al., 2025).
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Your brain hemispheres synchronise, promoting coherence, clarity, and creative thinking (Wang et al., 2025).
Stressful first thoughts?
The RAS filters your day through threat detection.
Grateful first thoughts?
It scans for opportunity, healing, and connection.
Your first thoughts are not neutral. They set your emotional and cognitive trajectory for the entire day (Yadav & Purushotham, 2025; Devaney et al., 2021).
You’re Not Just a Mind in a Body
You are an electromagnetic system living in a connected field of energy. Research now supports what mystics, monks, and performance experts have known for decades:
Your thoughts become biology. Your biology becomes behaviour. Your behaviour becomes your future.
When your intention (mental clarity) aligns with an elevated emotion (like awe, gratitude, or joy), you begin to create physiological coherence, a synchronised state between your brain, heart, and nervous system (Ahn et al., 2021; Bukkieva et al., 2022).
In this state:
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Synaptic pathways rewire
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Your immune system balances
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Emotional resilience strengthens
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Gene expression can shift
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Your nervous system "memorises" a new baseline (Valenta et al., 2025; Titone et al., 2023)
Your 7-Minute Morning Protocol
You don’t need technology. You don’t need a perfect routine.
You just need awareness and intention.
Here is a practical protocol, backed by neuroscience, to help you rewire your mind and body from the moment you wake up:
Step-by-Step 7-Minute Morning Protocol
You don’t need technology. You don’t need a perfect routine.
You need awareness and intention.
The first few minutes after waking are a powerful biological window—a period of heightened neuroplasticity and emotional influence. What you do in this time shapes how your nervous system responds to the world for the rest of the day.
Here’s a practical step-by-step protocol to guide those first moments with intention:
1. Wake Gently
Let your body come to naturally. Avoid harsh alarms that jolt your system into a stress response. Give yourself permission to rise slowly, without urgency.
2. Avoid Your Phone
Reaching for your phone immediately forces your brain into beta waves (high-alert mode), disrupting the slower, more programmable states of theta and alpha. Stay in the softness of waking. Let your internal world settle before external stimuli intrude.
3. Place Your Hand on Your Heart
This simple act grounds you. It activates the vagus nerve, supporting emotional regulation and heart-brain coherence. Let your attention settle into your body.
4. Breathe Slowly and Deeply
Inhale through the nose for 4 seconds, exhale through the mouth for 6. Repeat for 3 to 4 minutes. This breathing pattern supports parasympathetic activation—bringing calm, focus, and internal alignment.
5. Cultivate an Elevated Emotional State
Bring to mind someone or something you deeply love. Recall a moment of awe, joy, or deep gratitude. Smile gently. Let your body feel calm, safe, and expansive. This is not about performance—it’s about coherence.
6. Speak Like Your Future Self
Now that your system is receptive, introduce affirmations—spoken internally or aloud—as your future self would speak them. Use intentional, emotionally resonant language.
Here are some modern, grounded affirmations to guide you:
Personal Leadership & Direction
Affirmations that reinforce clarity, self-trust, and inner authority:
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“I lead my life with clarity and calm direction.”
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“I respond with purpose, not pressure.”
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“I honour progress over perfection today.”
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“I am becoming the version of me I respect.”
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“I trust my process. I’m already aligned.”
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“I am exactly where I need to be to take the next step.”
Resilience & Adaptability
Affirmations that support emotional flexibility and grounded strength:
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“Whatever arises, I meet it with presence and capacity.”
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“I am wired for change and built for resilience.”
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“Challenge sharpens me. I stay grounded in motion.”
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“I move from centre, not from stress.”
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“My nervous system is calm, and my mind is clear.”
Focus & Intentional Action
Affirmations that support mental clarity, focus, and productive intention:
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“Today I move with direction, not distraction.”
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“I choose energy that matches my intention.”
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“I prioritise what matters. The rest can wait.”
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“Peace is my default. Focus is my return point.”
Gratitude & Emotional Coherence
Affirmations that promote emotional alignment and heart-brain synchrony:
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“This day is a gift. I meet it with quiet strength.”
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“I feel supported, resourced, and ready.”
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“My heart leads. My body follows. My mind aligns.”
Each of these is a message to your nervous system, spoken as if the future is already embodied. Use them in stillness. Speak them with emotion. Let your physiology anchor the future you’re rehearsing.
7. Visualise Your Desired Reality
Now, visualise your ideal day, state, or outcome, not as a hope, but as if it has already occurred. Let it play in your mind’s eye with detail and emotional texture. This isn’t wishing. It’s rehearsing coherence.
Why It Works
This process works because it aligns with your biology:
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Neuroplasticity is at its peak during transitional states, especially when paired with strong emotions and repetition (Chen et al., 2025).
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The Reticular Activating System (RAS) filters your environment through the emotional lens you set at waking (Devaney et al., 2021).
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Coherence between heart and brain enhances clarity, memory, and immune response (Mueller et al., 2021; Jespersen et al., 2024).
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Repeating these patterns daily helps your nervous system establish them as a new baseline (Dennison, 2024; Ma et al., 2023).
Final Thoughts
The first seven minutes of your day are not a luxury. They are leverage.
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Coherence is the signal.
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Intention is the vector.
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Emotion is the charge.
So tomorrow morning, don’t scroll. Don’t rehearse stress.
Instead, tune your frequency.
Let your thoughts direct your biology. Let your body believe before your mind begins to doubt.
Your brain is listening.
Your cells are listening.
The field is listening.
Train it. Shape it. Repeat it.
References
Aggarwal, A. (2025). Brain connectivity using EEG data. https://doi.org/10.1101/2025.01.26.634935
Ahn, J., Lee, D., Namkoong, K., & Jung, Y. (2021). Altered functional connectivity of the salience network in problematic smartphone users. Frontiers in Psychiatry, 12. https://doi.org/10.3389/fpsyt.2021.636730
Bukkieva, T., Pospelova, M., Efimtsev, A., Fionik, O., Alekseeva, T., Samochernych, K., & Shevtsov, M. (2022). Functional network connectivity reveals the brain functional alterations in breast cancer survivors. Journal of Clinical Medicine, 11(3), 617. https://doi.org/10.3390/jcm11030617
Chen, J., Lewis, L., Coursey, S., Catana, C., Polimeni, J., Fan, J., & Rosen, B. (2025). Simultaneous EEG-PET-MRI identifies temporally coupled, spatially structured hemodynamic and metabolic dynamics across wakefulness and NREM sleep. https://doi.org/10.1101/2025.01.17.633689
Devaney, K., Levin, E., Tripathi, V., Higgins, J., Lazar, S., & Somers, D. (2021). Attention and default mode network assessments of meditation experience during active cognition and rest. Brain Sciences, 11(5), 566. https://doi.org/10.3390/brainsci11050566
Dennison, P. (2024). The enigma of jhāna and implications for neuroscience, consciousness studies and research methodology. https://doi.org/10.31219/osf.io/ncp25
Edlow, B., Olchanyi, M., Freeman, H., Li, J., Maffei, C., Snider, S., & Kinney, H. (2024). Multimodal MRI reveals brainstem connections that sustain wakefulness in human consciousness. Science Translational Medicine, 16(745). https://doi.org/10.1126/scitranslmed.adj4303
Hardikar, S., McKeown, B., Schaare, H., Wallace, R., Xu, T., Lauckner, M., & Smallwood, J. (2024). Macro-scale patterns in functional connectivity associated with ongoing thought patterns and dispositional traits. eLife, 13. https://doi.org/10.7554/eLife.93689
Jespersen, K., Stevner, A., Kringelbach, M., Someren, E., Vidaurre, D., & Vuust, P. (2024). Modelling of brain dynamics reveals reduced switching between brain states in insomnia disorder – a resting-state fMRI study. https://doi.org/10.1101/2024.11.27.625644
Ma, M., Li, Y., Shao, Y., & Weng, X. (2023). Effect of total sleep deprivation on effective EEG connectivity for young males in resting-state networks in different eye states. Frontiers in Neuroscience, 17. https://doi.org/10.3389/fnins.2023.1204457
Mueller, J., Pritschet, L., Santander, T., Taylor, C., Grafton, S., Jacobs, E., & Carlson, J. (2021). Dynamic community detection reveals transient reorganization of functional brain networks across a female menstrual cycle. Network Neuroscience, 5(1), 125–144. https://doi.org/10.1162/netn_a_00169
Negelspach, D., Kennedy, K., Huskey, A., Cha, J., Alkozei, A., & Killgore, W. (2025). Mapping the neural basis of wake onset regularity and its effects on sleep quality and positive affect. Clocks & Sleep, 7(1), 15. https://doi.org/10.3390/clockssleep7010015
Smallwood, J., Bernhardt, B., Leech, R., Bzdok, D., Jefferies, E., & Margulies, D. (2021). The default mode network in cognition: A topographical perspective. Nature Reviews Neuroscience, 22(8), 503–513. https://doi.org/10.1038/s41583-021-00474-4
Titone, S., Samogin, J., Peigneux, P., Swinnen, S., Mantini, D., & Albouy, G. (2023). Frequency-dependent connectivity in large-scale resting-state brain networks during sleep. European Journal of Neuroscience, 59(4), 686–702. https://doi.org/10.1111/ejn.16080
Valenta, S., Ventura, S., Benuzzi, F., Rizzello, F., Gionchetti, P., Ronchi, D., & Filippini, N. (2025). A heavy feeling in the stomach: Neural correlates of anxiety in Crohn’s disease. Neurogastroenterology & Motility, 37(7). https://doi.org/10.1111/nmo.70029
Wang, X., Peters, E., Strelen, J., Lockhart, N., Franklin, M., LaBerge, S., & Erlacher, D. (2025). EEG microstates reveal distinct network dynamics in lucid and non-lucid REM sleep. https://doi.org/10.1101/2025.02.12.637792
Yadav, A., & Purushotham, A. (2025). Cortical structure in nodes of the default mode network estimates general intelligence. Brain and Behavior, 15(5). https://doi.org/10.1002/brb3.70531
Yang, M. (2025). Study on large-scale brain network abnormalities in patients with beta-thalassemia. Brain and Behavior, 15(6). https://doi.org/10.1002/brb3.70614
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