One of the most important combinations of ingredients in RISE is the combination of Caffeine and Theanine.

Caffeine and theanine are compounds found in tea but have very different effects on our brains. Caffeine is a well-known stimulant that increases alertness and reduces fatigue, while theanine is an amino acid that promotes relaxation without sedation.

When combined, these two compounds can have a synergistic effect, enhancing cognitive performance and improving mood whilst regulating the sympathetic response we get from caffeine alone.

 

Caffeine: The Stimulant

  • Mechanism of Action: Caffeine works by blocking adenosine receptors in the brain. Adenosine is a neurotransmitter that promotes relaxation and sleepiness. By blocking these receptors, caffeine reduces the feeling of tiredness and increases alertness (Smith, 2002) .
  • Benefits: Increased energy, enhanced focus, improved reaction times, and elevated mood.
  • Drawbacks: Can cause jitteriness, anxiety, increased heart rate, and potential for a "crash" when its effects wear off.

 

Theanine: The Calmer

  • Mechanism of Action: Theanine promotes the production of calming neurotransmitters like GABA, dopamine, and serotonin. It also modulates alpha brain waves, associated with a relaxed yet alert mental state (Kimura et al., 2007)—one of the reasons you will also find it in HMN24 Pre-Sleep.
  • Benefits: Reduces stress and anxiety, promotes relaxation without drowsiness, and can improve sleep quality (Lyon et al., 2011).
  • Drawbacks: Theanine doesn’t have strong stimulant or sedative effects on its own, so its impact might be subtle.

 

Combining Caffeine and Theanine

  • Balanced Effects: The combination of caffeine and theanine provides the stimulating benefits of caffeine without the jitteriness or anxiety that can sometimes accompany caffeine consumption. Theanine helps smooth out the stimulant effects, leading to calm alertness and the regulated nervous system stimulation we all desire (Haskell et al., 2008).
  • Cognitive Enhancement: Studies have shown that the combination can improve cognitive performance more effectively than either compound alone. This includes better attention, memory, and learning capabilities (Owen et al., 2008).
  • Mood Improvement: Theanine’s calming effects can counteract caffeine’s potential anxiety-inducing effects, leading to a more stable and improved mood (Rogers & Smith, 2011).

 

Scientific Evidence

Numerous studies have investigated the effects of combining caffeine and theanine:

Improved Attention and Accuracy: Research has shown that the combination can significantly enhance attention and accuracy in tasks requiring fast information processing (Einöther & Giesbrecht, 2013).

Enhanced Alertness and Relaxation: Participants report feeling more alert yet relaxed when taking both compounds together (Giesbrecht et al., 2010).

Reduced Jitteriness: Theanine's calming effects help mitigate the jitteriness often associated with caffeine, making it easier to focus without the distraction of feeling overly stimulated (Foxe et al., 2012).

 

Practical Applications

Dosage: Ratios used in studies vary but the 2:1 ratio of theanine to caffeine, such as 250mg of theanine and 125 mg of caffeine that you find in HMN24 RISE is the ratio with the most robust evidence.

 

Summary

Combining caffeine with theanine leverages the stimulating properties of caffeine and the calming effects of theanine to enhance cognitive performance, improve mood, and reduce the adverse side effects of caffeine.

This synergy creates the balanced state of increased alertness and relaxation, mental clarity, and focus we strive for when using RISE. It also helps us regulate and manage our all-important nervous system activity far more than with caffeine alone.

 

References:

Smith, A. (2002). Effects of caffeine on human behaviour. Food and Chemical Toxicology, 40(9), 1243-1255.
Einöther, S. J. L., & Giesbrecht, T. (2013). Caffeine as an attention enhancer: reviewing existing assumptions. Psychopharmacology, 225(2), 251-274.
Kimura, K., Ozeki, M., Juneja, L. R., & Ohira, H. (2007). L-Theanine reduces psychological and physiological stress responses. Biological Psychology, 74(1), 39-45.
Lyon, M. R., Kapoor, M. P., & Juneja, L. R. (2011). The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomised, double-blind, placebo-controlled clinical trial. Alternative Medicine Review, 16(4), 348-354.
Owen, G. N., Parnell, H., De Bruin, E. A., & Rycroft, J. A. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutritional Neuroscience, 11(4), 193-198.
Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., & Scholey, A. B. (2008). The effects of L-theanine, caffeine and their combination on cognition and mood. Biological Psychology, 77(2), 113-122.
Giesbrecht, T., Rycroft, J. A., Rowson, M. J., & De Bruin, E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional Neuroscience, 13(6), 283-290.
Einöther, S. J. L., & Martens, V. E. G. (2013). Acute effects of tea consumption on attention and mood. American Journal of Clinical Nutrition, 98(6), 1700S-1708S.
Einöther, S. J. L., & Giesbrecht, T. (2013). Caffeine as an attention enhancer: reviewing existing assumptions. Psychopharmacology, 225(2), 251-274.
Foxe, J. J., Morie, K. P., Laud, P. J., Rowson, M. J., De Bruin, E. A., & Kelly, S. P. (2012). Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task. Neuropharmacology, 62(7), 2320-2327.
Rogers, P. J., & Smith, J. E. (2011). Positive mood and cognitive performance: the synergistic effect of L-theanine and caffeine. Psychopharmacology, 217(2), 221-229.
Owen, G. N., Parnell, H., De Bruin, E. A., & Rycroft, J. A. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutritional Neuroscience, 11(4), 193-198.